Brain Hypoxia and Ischemia

3,000 تومان

Brain Hypoxia and Ischemia
Gabriel G. Haddad · Shan Ping Yu
with Special Emphasis on Development
2009
pages 345

توضیحات

Brain Hypoxia and Ischemia

This is a book that has resulted from many discussions and meetings that the editors
have had in last few years around mechanisms of cell death and cell survival
under stressful conditions in the central nervous system (CNS). Indeed some of
the authors of this book participated in a symposium that was organized by the
editors at the Society for Neuroscience several years ago. The various aspects of
cell death/survival and questions that are addressed here are by and large issues
that are crucial for the understanding of the basic mechanisms underlying brain
hypoxia and ischemia. The hope is that by understanding these mechanisms we
would be better armed to devise much better ways for the diagnosis and treatment
of diseases that afflict the brain and potentially other organs when O2 levels
.are dysregulated
Although some overlap between chapters was impossible to prevent, various
chapters in this book address specific questions that we believe are critical at this
stage of the science. These chapters focus on a panorama of issues, from the role
of ion channels/transporters to that of mitochondria and apoptotic mechanisms, to
the role of glutamate/NMDA, to the mechanisms in penumbral cells, to the importance
of intermittent hypoxia, and certainly to gene regulation under these stressful
,conditions. While most chapters focus on mammalian models and mechanisms
some chapters center around invertebrate systems since these have proven to be
exceedingly important in helping us with mammalian and even human systems
.and diseases
Although there is evidence that the newborn or young mammalian CNS is more
tolerant than the mature differentiated system, there is also plenty of evidence that
.the newborn CNS is vulnerable to various stresses including hypoxia and ischemia
Whether the mechanisms are the same or different, whether the vulnerable regions
are the same, and how maturation of certain systems can affect survival or injury
are all important questions that have major clinical implications at the bedside. This
.is why this book has a bent toward development
We believe that this is the first book that has such a panorama of chapters – all in
one book – summarizing the state of our knowledge in this area. We are especially
excited about the intriguing novel discoveries described in many chapters in this
book. The idea is to stimulate and stir discussions around these questions by
exposing current knowledge and in so doing the state of our ignorance. We believe
that neuroscientists, clinicians, and medical/graduate students will find this book
.useful for both basic research and clinical practice